Bound together by their Ivy League educations and boardroom successes, four prominent Manhattan women – Zoe Burden, Mia Mason, Juliet Draper, and Caitlin Dowd – are living the lives that others only dream of. The youngest ever Managing Director at a big investment bank, Zoe is constantly trying to strike just the right balance between the demands of her career and those of a being wife and mother. Her business school classmate Mia is climbing the ladder to the top of a magazine publishing group, while Juliet, the COO of a large luxury hotel chain, is a fierce competitor in the boardroom as well as a successful charity fundraiser. And cosmetics company executive Caitlin has a brilliant track record at work that stands in stark contrast to an unsatisfying romantic life.